PROMISCES aims to increase the circularity of resources by overcoming barriers associated with the presence of industrial Mobile, Perstistent and Potentially Toxic chemicals (iPM(T)s) in the soil-sediment-water system. To reach this overall goal the main innovation and research objectives are:

Anhang 1

PROMISCES develops and demonstrates target and non-target methods for the identification and quantification of PFAS and iPM(T)s substances in the soil-sediment water system along different circular economy routes and complex matrices. It will provide knowledge on PFAS transfer and conversion factors during nutrient and material recovery and develop monitoring strategies for complex emission and transport situations. These will be validated under field conditions.

PROMISCES provides innovative and integrative modelling approaches to predict fate and transport pathways for PFAS and iPM(T)s substances in environmental compartments (Soil-Sediment-Water system) by combining specific monitoring data on sources and transport of iPM(T)s with open-source modelling tools. In addition, quantitative structure-property relationships (QSPR) models, in silico similarity tools and artificial intelligence (AI) will be applied to complete knowledge on iPM(T)s properties.

Concretely, PROMISCES develops novel regulatory tools, integrated in vitro testing strategies and toxicological assessment tools to evaluate remediation efficiency. A holistic assessment strategy combining in vitro bioassays and in silico toxicity modelling will be developed for screening, early warning, and prioritisation of chemicals of unknown toxicity or groups of chemicals. PROMISCES will improve the knowledge on the epistemic uncertainty related to probabilistic human health risk assessment (HHRA) for PFAS/iPM(T)s, while addressing data scarcity and options for decision making under uncertainty. PROMISCES will further develop modelling tools to allow better early warning and decision making to protect human health.

PROMISCES develops and demonstrates effective and sustainable technologies to remediate PFAS and iPMT(s) in soils, dredged sediments, and groundwater as well as drinking water, industrial and municipal wastewater and concentrated liquids.

PROMISCES provides a suite of assessment and regulatory tools for improving human health protection related to resource recovery and use. This includes an integrated Decision Support Framework (DSF) to assist key stakeholders in the selection of systemic solutions for preventing, mitigating, and remediating risks associated with the presence of iPM(T)s in circular systems, in connection with EU strategies, specifically the Zero pollution and Circular Economy Action plans.

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